abstract：:Although 17beta-estradiol (E2) administration following trauma-hemorrhage (T-H) improves cardiac function in male rodents, it is not known whether the salutary effects of E2 are mediated via estrogen receptor (ER)-alpha or ER-beta, and whether cardiac heat shock proteins (Hsp) are affected by E2 administration. Male S...

journal_title：Journal of molecular and cellular cardiology

authors： Yu HP,Shimizu T,Choudhry MA,Hsieh YC,Suzuki T,Bland KI,Chaudry IH

更新日期：2006-01-01 00:00:00

abstract：:Transforming growth beta-1 (TGF-beta1) appears to play a critical role in the regulation of arterial intimal growth and the development of atherosclerosis. TGF-beta1 is expressed at increased levels in diseased arteries; however, its role in disease development remains controversial. Experiments in which TGF-beta1 is ...

journal_title：Journal of molecular and cellular cardiology

authors： Lee S,Agah R,Xiao M,Frutkin AD,Kremen M,Shi H,Dichek DA

更新日期：2006-01-01 00:00:00

abstract：:Lack of endothelial nitric oxide synthase (eNOS) may affect the sensitivity of cyclic GMP signaling through soluble guanylyl cyclase (sGC). We hypothesized that in eNOS knockout (eNOS-/-) mice, stimulation of guanylyl cyclase would have enhanced effects inhibiting cardiac contraction. We measured cell shortening and c...

journal_title：Journal of molecular and cellular cardiology

authors： Su J,Tse J,Scholz PM,Weiss HR

更新日期：2005-12-01 00:00:00

abstract：:The p66shc adaptor protein mediates age-associated oxidative stress. We examined the role of p66shc in endothelial nitric oxide synthase (eNOS) signaling. Overexpression of p66shc inhibited eNOS-dependent NO production. RNAi-mediated down-regulation of endogenous p66shc led to activation of the proto-oncogene ras, and...

journal_title：Journal of molecular and cellular cardiology

authors： Yamamori T,White AR,Mattagajasingh I,Khanday FA,Haile A,Qi B,Jeon BH,Bugayenko A,Kasuno K,Berkowitz DE,Irani K

更新日期：2005-12-01 00:00:00

abstract：:Human vascular smooth muscle cells (HVSMCs) are resistant to Fas-mediated death under normal physiological conditions. However, HVSMC death by activation of the receptor pathway was reported in the atherosclerotic lesions. In this study, we investigated whether 7-ketocholesterol, one of the major cholesterol oxides in...

journal_title：Journal of molecular and cellular cardiology

authors： Rho MC,Kim YK,Chang JS,Lee HS,Baek JA,Chung MY,Lee HC,Lee HW,Rhim BY,Reidy MA,Kim K

更新日期：2005-11-01 00:00:00

abstract：:The opening of mitochondrial permeability transition pore (PTP) during reperfusion injury of heart has been well demonstrated and thus controlling PTP would attenuate the myocardial damage and cell death. Ursodeoxycholic acid (UDCA) is a hydrophilic bile salt and has been shown to prevent apoptosis in hepatocytes by i...

journal_title：Journal of molecular and cellular cardiology

authors： Rajesh KG,Suzuki R,Maeda H,Yamamoto M,Yutong X,Sasaguri S

更新日期：2005-11-01 00:00:00

abstract：:Adequate wound healing and scar formation is an essential response to myocardial infarction (MI), and fibroblasts are primary cellular components regulating the process. How fibroblast functions are altered post-MI and to what extent these abnormalities persist in vitro is not well understood. Accordingly, we isolated...

journal_title：Journal of molecular and cellular cardiology

authors： Squires CE,Escobar GP,Payne JF,Leonardi RA,Goshorn DK,Sheats NJ,Mains IM,Mingoia JT,Flack EC,Lindsey ML

更新日期：2005-10-01 00:00:00

abstract：:The lack of pathological consequences of cardiac ATP-sensitive potassium channel (K(ATP)) channel gene manipulation is in stark contrast to the effect of similar perturbations in the pancreatic beta-cell. Because the pancreatic and cardiac channel share the same pore-forming subunit (Kir6.2), the different effects of ...

journal_title：Journal of molecular and cellular cardiology

authors： Flagg TP,Remedi MS,Masia R,Gomes J,McLerie M,Lopatin AN,Nichols CG

更新日期：2005-10-01 00:00:00

abstract：:Inflammatory mediators have been implicated as a cause of reversible myocardial depression in septic shock. We previously reported that the release of lysozyme-c (Lmz-S) from leukocytes from the spleen or other organs contributes to myocardial dysfunction in Escherichia coli septic shock in dogs by binding to a cardia...

journal_title：Journal of molecular and cellular cardiology

authors： Mink SN,Bose R,Roberts DE,Jacobs H,Duke K,Bose D,Cheng ZQ,Light RB

更新日期：2005-10-01 00:00:00

abstract：:We hypothesized that chronic xanthine oxidase inhibition (XOI) would have favorable effects on both ventricular and vascular performance in evolving heart failure (HF), thereby preserving ventricular-vascular coupling. In HF, XOI reduces oxidative stress and improves both vascular and myocardial function. Dogs were ra...

journal_title：Journal of molecular and cellular cardiology

authors： Amado LC,Saliaris AP,Raju SV,Lehrke S,St John M,Xie J,Stewart G,Fitton T,Minhas KM,Brawn J,Hare JM

更新日期：2005-09-01 00:00:00

abstract：:To establish new treatment for cardiovascular disease, the development of safe and highly efficient vectors is necessary. Especially, non-viral vectors are considered to be ideal for human gene therapy, since recent adverse events with retroviral or adenoviral vectors have highlighted the issue of safety. Although we ...

journal_title：Journal of molecular and cellular cardiology

authors： Tashiro H,Aoki M,Isobe M,Hashiya N,Makino H,Kaneda Y,Ogihara T,Morishita R

更新日期：2005-09-01 00:00:00

abstract：:Ischemic tolerance decreases with aging and the cardioprotective effect of ischemic preconditioning (IPC) is impaired in aged animals. Although lifelong caloric restriction (CR) profoundly affects the physiological and pathophysiological modifications induced by aging and markedly increases life span in several specie...

journal_title：Journal of molecular and cellular cardiology

authors： Shinmura K,Tamaki K,Bolli R

更新日期：2005-08-01 00:00:00

abstract：:Myocardial infarction leads to scar formation and subsequent reduced cardiac performance. The ultimate therapy after myocardial infarction would pursue stem cell-based regeneration. The aim of stem cell-mediated cardiac repair embodies restoration of cardiac function by regeneration of healthy myocardial tissue, which...

journal_title：Journal of molecular and cellular cardiology

authors： Vandervelde S,van Luyn MJ,Tio RA,Harmsen MC

更新日期：2005-08-01 00:00:00

abstract：:Defective sarcoplasmic reticulum (SR) Ca2+ handling is evident in cardiomyopathy and may be mediated by selective dysregulation of SR Ca2+ handling proteins. To assess whether regulation of SR Ca2+ release may vary regionally within the normal and diseased heart, left ventricular transmural expression and activity of ...

journal_title：Journal of molecular and cellular cardiology

authors： Currie S,Quinn FR,Sayeed RA,Duncan AM,Kettlewell S,Smith GL

更新日期：2005-08-01 00:00:00

abstract：:Previous studies have demonstrated that acute ethanol exposure induces activation of delta protein kinase C (deltaPKC) and epsilonPKC, and mimics ischemic preconditioning via epsilonPKC activation. However, the role of deltaPKC isozyme in ischemia and reperfusion is still controversial. Here, we investigated the role ...

journal_title：Journal of molecular and cellular cardiology

authors： Inagaki K,Mochly-Rosen D

更新日期：2005-08-01 00:00:00

abstract：:The ATP-sensitive K(+) (K(ATP)) channel is composed of four pore-forming Kir6.2 subunits and four sulfonylurea receptors (SUR). Intracellular ATP inhibits K(ATP) channels through Kir6.2. SUR is an ABC protein bearing transmembrane domains and two nucleotide-binding domains (NBD1 and NBD2). SUR increases the open proba...

journal_title：Journal of molecular and cellular cardiology

authors： Yamada M,Kurachi Y

更新日期：2005-07-01 00:00:00

abstract：:In the mouse, genetic reduction in the Na(+), K(+)-ATPase alpha1 or alpha2 isoforms results in different functional phenotypes: heterozygous alpha2 isolated hearts are hypercontractile, whereas heterozygous alpha1 hearts are hypocontractile. We examined Na(+)/Ca(2+) exchange (NCX) currents in voltage clamped myocytes ...

journal_title：Journal of molecular and cellular cardiology

authors： Yamamoto T,Su Z,Moseley AE,Kadono T,Zhang J,Cougnon M,Li F,Lingrel JB,Barry WH

更新日期：2005-07-01 00:00:00

abstract：:The sulfonylurea receptor SUR is an ATP binding cassette (ABC) protein of the ABCC/MRP family. Unlike other ABC proteins, it has no intrinsic transport function, neither active nor passive, but associates with the potassium channel proteins Kir6.1 or Kir6.2 to form the ATP-sensitive potassium (K(ATP)) channel. Within ...

journal_title：Journal of molecular and cellular cardiology

authors： Moreau C,Prost AL,Dérand R,Vivaudou M

更新日期：2005-06-01 00:00:00

abstract：:Peroxynitrite is a potent oxidant and nitrating species proposed as a direct effector of myocardial damage in a wide range of cardiac diseases. Whether peroxynitrite also acts indirectly, by modulating cell signal transduction pathways in the myocardium, has not been investigated. Here, we examined the ability of pero...

journal_title：Journal of molecular and cellular cardiology

authors： Pesse B,Levrand S,Feihl F,Waeber B,Gavillet B,Pacher P,Liaudet L

更新日期：2005-05-01 00:00:00

abstract：:The very low-density lipoprotein (VLDL) receptor is a member of the low-density lipoprotein (LDL) receptor gene family with distinct tissue distribution and function. VLDL receptors are also expressed in vascular smooth muscle cells (VSMCs) and have been shown to be upregulated in atherosclerotic lesions. In the prese...

journal_title：Journal of molecular and cellular cardiology

authors： Takahashi M,Takahashi S,Suzuki C,Jia L,Morimoto H,Ise H,Iwasaki T,Hattori H,Suzuki J,Miyamori I,Kobayashi E,Ikeda U

更新日期：2005-04-01 00:00:00

abstract：:Angiotensin (Ang) II plays an important role in post-myocardial infarction (MI) cardiac remodeling. The Ang II type 1 (AT(1)) receptor which mediates most Ang II effects is upregulated on non-myocytes in the post-MI heart. We have shown that pro-inflammatory cytokines increase AT(1) receptor density on cardiac fibrobl...

journal_title：Journal of molecular and cellular cardiology

authors： Gurantz D,Cowling RT,Varki N,Frikovsky E,Moore CD,Greenberg BH

更新日期：2005-03-01 00:00:00

abstract：:Endothelial cells (ECs) in normal vessels are poorly transducible by retroviral vectors, which require cell division for gene transduction. Among retroviruses, lentiviruses have the unique ability to integrate their genome into the chromatin of nondividing cells. Here we show that multiply attenuated, self-inactivatin...

journal_title：Journal of molecular and cellular cardiology

authors： Céfaï D,Simeoni E,Ludunge KM,Driscoll R,von Segesser LK,Kappenberger L,Vassalli G

更新日期：2005-02-01 00:00:00

abstract：:The BH3-only proteins, including BNip3, are members of the Bcl-2 family of cell death-regulating factors. Whereas proteins such as Bax and Bak play a central role in most forms of apoptosis, the BH3-only proteins appear to modulate apoptosis through cell type- and signal-specific pathways. This review will focus on ou...

journal_title：Journal of molecular and cellular cardiology

authors： Webster KA,Graham RM,Bishopric NH

更新日期：2005-01-01 00:00:00

abstract：:The mechanism by which Na+-H+ exchange (NHE) inhibition results in attenuation and reversal of postinfarction remodelling and heart failure remains controversial. In this study, we investigated the possible contribution of mitochondrial involvement by determining the effect of the NHE-1-specific inhibitor EMD-87580 (E...

journal_title：Journal of molecular and cellular cardiology

authors： Javadov S,Huang C,Kirshenbaum L,Karmazyn M

更新日期：2005-01-01 00:00:00

abstract：:In the past decade, genetic modification has been extensively employed to define (patho)physiological roles of chaperones and the cytoskeleton in the heart, promoting dramatic advances in this field. Both loss-of-function and gain-of-function approaches have been used productively. alphaB-Crystallin (CryAB) is the mos...

journal_title：Journal of molecular and cellular cardiology

authors： Kumarapeli AR,Wang X

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVE:The function of the C-terminus region of the human ether-a-go-go related gene (HERG) has not been well characterized except for its involvement in trafficking. To understand further the role of C-terminus region, we performed a functional analysis of a novel frameshift mutation (1122fs/147) identified in a Ja...

journal_title：Journal of molecular and cellular cardiology

authors： Sasano T,Ueda K,Orikabe M,Hirano Y,Kawano S,Yasunami M,Isobe M,Kimura A,Hiraoka M

更新日期：2004-12-01 00:00:00

abstract：:Following diazoxide (DZ) induced hypoinsulinemia, cardiac luminal lipoprotein lipase (LPL) increases [Cardiovasc. Res. 3 (2003) 788]. To identify circulating mediators that maintain high LPL in vivo, DZ hearts were perfused for 1 h in the presence or absence of glucose, triglyceride (TG), palmitic acid or palmitoyl ly...

journal_title：Journal of molecular and cellular cardiology

authors： Pulinilkunnil T,An D,Yip P,Chan N,Qi D,Ghosh S,Abrahani A,Rodrigues B

更新日期：2004-11-01 00:00:00

abstract：:Various drugs are reported to prolong the QT-interval on the surface ECG, thereby increasing the risk of developing a potentially fatal arrhythmia known as Torsades de Pointes (TdP). TdP case reports for these drugs have often been associated with risk factors such as overdosing, concomitant drugs and/or existing path...

journal_title：Journal of molecular and cellular cardiology

authors： Sun Z,Milos PM,Thompson JF,Lloyd DB,Mank-Seymour A,Richmond J,Cordes JS,Zhou J

更新日期：2004-11-01 00:00:00

abstract：:The ability of the myocardium to successfully adapt to cardiac injury ultimately determines whether the heart will decompensate and fail, or whether instead it will maintain preserved function. Despite the importance of the myocardial response to cardiac injury, very little is known with respect to the biochemical mec...

journal_title：Journal of molecular and cellular cardiology

authors： Wilson EM,Diwan A,Spinale FG,Mann DL

更新日期：2004-10-01 00:00:00

abstract：UNLABELLED:We assessed the possibility to detect intracellular nitric oxide (NO) with the NO-specific probe 4,5-diaminofluorescein-2/diacetate (DAF-2/DA), by flow cytometry, in fresh adult rat cardiomyocytes, and compared the findings with results obtained from quantitation of cellular nitrate/nitrite (NO(x)) levels. ...

journal_title：Journal of molecular and cellular cardiology

authors： Strijdom H,Muller C,Lochner A

更新日期：2004-10-01 00:00:00

abstract：:The aims of our study were to determine mortality, and age- and genotype-related cardiac phenotype in endothelial nitric oxide synthase (NOS) knockout (-/-) and wild-type (+/+) mice. Male and female (-/-) and male and female (+/+) conscious mice were studied at different ages by echocardiography and tail-cuff blood pr...

journal_title：Journal of molecular and cellular cardiology

authors： Li W,Mital S,Ojaimi C,Csiszar A,Kaley G,Hintze TH

更新日期：2004-09-01 00:00:00

abstract：:The mechanism responsible for cardiac depression in septic shock remains unknown. The present study examined whether nitric oxide (NO) overproduced by inducible NO synthase (iNOS) can inhibit aerobic energy metabolism and impair the myocardial function in endotoxin-treated rat hearts. Lipopolysaccharide (LPS) signific...

journal_title：Journal of molecular and cellular cardiology

authors： Tatsumi T,Akashi K,Keira N,Matoba S,Mano A,Shiraishi J,Yamanaka S,Kobara M,Hibino N,Hosokawa S,Asayama J,Fushiki S,Fliss H,Nakagawa M,Matsubara H

更新日期：2004-09-01 00:00:00

abstract：:Heterotrimeric G-proteins, composed of Galpha and Gbetagamma subunits, transmit numerous and diverse extracellular stimuli via a large family of heptahelical cell-surface receptors to various intracellular effector molecules. The Gbetagamma subunit plays a central role in G-protein signaling. The Gbeta subunit belongs...

journal_title：Journal of molecular and cellular cardiology

authors： Chen S,Spiegelberg BD,Lin F,Dell EJ,Hamm HE

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:Mitochondrial calcium overload is an important factor in defining ischemia/reperfusion injury. Since pre-menopausal women are relatively protected from ischemia and heart disease, we tested the hypothesis that gender differences alter Ca(2+) handling in rat cardiac mitochondria. METHODS:Using cardiac mitoch...

journal_title：Journal of molecular and cellular cardiology

authors： Arieli Y,Gursahani H,Eaton MM,Hernandez LA,Schaefer S

更新日期：2004-08-01 00:00:00

abstract：:Multiple studies have shown that phospholamban (PLN) plays a key role in regulation of frequency-dependent increase of cardiac contraction, a hallmark of the contractile reserve in myocardium. However, the mechanisms underlying this relationship remain elusive. Phosphorylation of PLN occurs on residues: serine-16 (Ser...

journal_title：Journal of molecular and cellular cardiology

authors： Zhao W,Uehara Y,Chu G,Song Q,Qian J,Young K,Kranias EG

更新日期：2004-08-01 00:00:00

abstract：:Ca(2+) overload and free-radical injury are two mutually non-exclusive phenomena suggested to cause myocardial ischemia-reperfusion (IR)-induced contractile dysfunction; however, the mechanisms underlying their effects are not clear. One possible mechanism is the proteolytic modification of proteins by Ca(2+)-dependen...

journal_title：Journal of molecular and cellular cardiology

authors： Singh RB,Chohan PK,Dhalla NS,Netticadan T

更新日期：2004-07-01 00:00:00

abstract：:Aquaporins (AQPs) are a family of water channel proteins that assist in maintenance of the cellular osmotic environment and whole body fluid balance. Specialized organ-specific AQPs are important in physiologic and pathologic processes but little is known about AQPs in the human heart. AQP1 has been identified in rode...

journal_title：Journal of molecular and cellular cardiology

authors： Au CG,Cooper ST,Lo HP,Compton AG,Yang N,Wintour EM,North KN,Winlaw DS

更新日期：2004-05-01 00:00:00

abstract：:An increase in circulating brain natriuretic peptide (BNP) but not atrial natriuretic factor (ANF) is observed coincident with cardiac allograft rejection that is reversed upon treatment with anti-lymphocyte therapy suggesting that pro-inflammatory cytokines may uniquely modulate BNP gene expression and secretion. Thi...

journal_title：Journal of molecular and cellular cardiology

authors： Ma KK,Ogawa T,de Bold AJ

更新日期：2004-04-01 00:00:00

abstract：:One of the major issues in myocardial gene therapy is poor transfection efficiency. The herpes simplex virus protein VP22 is known to facilitate intercellular protein transport. Not only VP22 but also VP22-linked protein are exported from the cytoplasm of cells, in which it is synthesised endogenously, and transferred...

journal_title：Journal of molecular and cellular cardiology

authors： Suzuki K,Murtuza B,Brand NJ,Varela-Carver A,Fukushima S,Yacoub MH

更新日期：2004-04-01 00:00:00

abstract：:The adenosine A1/A2 adenosine agonist 5'-(N-ethylcarboxamido) adenosine (NECA) and bradykinin both limit infarction when administered at reperfusion in rabbits. This study compares the signal transduction pathways responsible for their anti-infarct effect. Receptor agonists were administered to isolated rabbit hearts ...

journal_title：Journal of molecular and cellular cardiology

authors： Yang XM,Krieg T,Cui L,Downey JM,Cohen MV

更新日期：2004-03-01 00:00:00